MRI Research Presentation by Associate Professor Leighton Barnden

MRI manifestation of brainstem regulatory deficits in ME/CFS

A researcher from the National Centre for Neuroimmunology and Emerging Diseases (NCNED), Associate Professor Leighton Barnden presented their MRI research at the ME/CFS International Conference 2021:RID held in November last year.

The NCNED has shared the recording of the Associate Professor’s presentation on their Facebook page.

https://www.facebook.com/watch/?v=326899692658292

We believe the high standard of medical research into Myalgic Encephalomyelitis (ME) from the NCNED will play a critical role in improving the quality of healthcare for people with ME.

We hope the evidence from their research will be implimented into clinical care to advance health for people with ME at our future ME Clinic.


For those who wish to learn more about Neuroimaging research, the NCNED kindly provided the list of publications included in the presentation.

Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis/chronic fatigue syndrome

Thapaliya K, Marshall-Gradisnik S, Staines D, Barnden L: Diffusion tensor imaging reveals neuronal microstructural changes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: European Journal of Neuroscience, 2021 https://doi.org/10.1111/ejn.15413

Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans

Thapaliya K, Marshall-Gradisnik S, Staines D, Barnden L: Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2- weighted MRI scans: Neuroimage Clinical 28: 2020 https://doi.org/10.1016/j.nicl.2020.102366

A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques

Maksoud R, du Preez S, Eaton-Fitch N, Thapaliya K, Barnden L, Cabanas H, Staines D, Marshall-Gradisnik S: A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques: Public Library of Science 15(4) 2020 https://doi.org/10.1371/journal.pone.0232475

Intra brainstem connectivity is impaired in chronic fatigue syndrome

Barnden L, Shan Z, Staines D, Marshall-Gradisnik S, Finegan K, Ireland T, Bhuta S: Intra brainstem connectivity is impaired in chronic fatigue syndrome: Neuroimage Clinical, 2019 https://doi.org/10.1016/j.nicl.2019.102045

Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome

Barnden L, Shan Z, Staines D, Marshall-Gradisnik S, Finegan K, Ireland T, Bhuta S: Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome. NeuroImage Clinical, 2018, 20:102-109. https://doi.org/10.1016/j.nicl.2018.07.011

Brain function characteristics of chronic fatigue syndrome: A task fMRI study

Shan ZY, Finegan K, Bhuta S, Ireland T, Staines D, Marshall-Gradisnik S, Barnden L: Brain function characteristics of Chronic Fatigue Syndrome: a task fMRI study. Neuroimage: Clinical, 2018, 19:279-286. IF 4.515. • https://doi.org/10.1016/j.nicl.2018.04.025

Decreased Connectivity and Increased Blood Oxygenation Level Dependent Complexity in the Default Mode Network in Individuals with Chronic Fatigue Syndrome

Shan ZY, Finegan K, Bhuta B, Ireland T, Staines DR, Marshall-Gradisnik S, Barnden LR: Decreased connectivity and increased blood oxygenation level dependant complexity in the default mode network in individuals with Chronic Fatigue Syndrome. Brain Connectivity, 2018, 8(1):33-39. IF 3.83. https://doi.org/10.1089/brain.2017.0549

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with Chronic Fatigue Syndrome. NMR in Biomedicine

Shan ZY, Kwiatek R, Burnet R, Del Fante P, Staines DR, MarshallGradisnik SM, Barnden LR: Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with Chronic Fatigue Syndrome. NMR in Biomedicine, 2017, 30(10). IF 3.53, Cited 2. https://doi.org/10.1002/nbm.3757

Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome

Barnden LR, Kwiatek R, Crouch B, Burnet R, Del Fante P: Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome. NeuroImage: Clinical, 2016, 11:530-537. https://doi.org/10.1016/j.nicl.2016.03.017 IF 5.15, Cited 10.

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Shan ZY, Kwiatek R, Burnet R, Del Fante P, Staines DR, MarshallGradisnik SM, Barnden LR: Progressive brain changes in pients with Chronic Fatigue Syndrome: A longitudinal MRI study (https://www.ncbi.nlm.nih.gov/pubmed/27123773). Journal of Magnetic Resonance Imaging, 2016, 44(5):1301-1311. IF 3.083, Cited 3.

Evidence in Chronic Fatigue Syndrome for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression

Barnden LR, Crouch B, Kwiatek R, Burnet R, Del Fante P: Evidence in Chronic Fatigue Syndrome for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression (https://pubmed.ncbi.nlm.nih.gov/25702943/). NMR in Biomedicine, 2015, 28(3):404-413. doi: 10.1002/nbm.3261. IF 3.53, Cited 15.

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